Objective To explore the detection and clinical significance of serum 25 hydroxyvitamin D[25(OH)D],ferritin(SF)and glycosylated hemoglobin(HbA1c)levels in patients with gestational diabetes(GDM).Methods Sixty GDM patients who underwent prenatal examination at Zhengzhou Maternal and Child Health Hospital from January 2021 to July 2023 were selected as the GDM group,and 60 healthy postpartum women were selected as the control group.5 ml of cubital veinblood was collected from the group subjects under fasting state,and the supernatant was centrifuged.SF and 25(OH)D were measured using electrochemical luminescence immunoassay(ECLIA),and HbA1c was measured using latex enhanced immunoturbidimetry.Comparing the differences in the detection values of SF,25(OH)D,and HbA1c between two groups of pregnant women,logistic regression analysis showed the relationship between the three and the onset of GDM,and the receiver operating characteristic(ROC)curve was plotted to analyze the value of combined detection of SF,25(OH)D,and HbA1c in the diagnosis of GDM.The results showed that the detection values of SF and HbA1c in the GDM group were higher than those in the control group,while the detection values of 25(OH)D were lower than those in the control group(P<0.05);Logistic regression analysis showed that SF(β value=2.559,OR(95%CI)=12.923(3.665,45.571),25(OH)D(β value=-0.022,OR(95%CI)=-3.667(-5.967,0.990),HbA1c(β value=1.128,OR(95%CI)= 4.355(1.860,5.133)are all high-risk factors for the onset of GDM(P<0.05).The area under the curve(AUC)for SF diagnosis of GDM is 0.747[asymptotic 95%CI:(0.659,0.838)],sensitivity is 0.750,specificity is 0.717,and Jordan index is 0.467;The AUC for diagnosing GDM with 25(OH)D is 0.728[asymptotic 95%CI:(0.637,0.820)],sensitivity is 0.717,specificity is 0.633,and Jordan index is 0.350;The AUC of HbA1c in diagnosing GDM is 0.780[asymptotic 95%CI:(0.697,0.863)],sensitivity is 0.800,specificity is 0.767,Jordan index is 0.567,and the AUC of SF,25(OH)D,and HbA1c combined detection in diagnosing GDM is 0.855(asymptotic 95%CI:(0.786,0.924)],sensitivity is 0.883,specificity is 0.783,and Jordan index is 0.666,all of which are higher than single detection of each indicator.Conclusion The abnormal levels of serum SF,25(OH)D,and HbA1c in GDM patients are all related to the onset of GDM.Combined detection can improve the detection rate of GDM.
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