Objective To study the clinicopathologic features,immunohistochemical staining,diagnosis and differential diagnosis,treatment and prognosis in sebaceous carcinoma(SC)of the eyelids.Methods The clini-cal manifestations,histopathological features,immunohistochemisty,treatment and prognosis were analyzed in 7 cases of SC with review of the literature.Results The patients included 3 males and 4 females,with an average age of 67 years old(ranged from 50 to 84 years old).Microscopically,the tumor cells arranged in a infiltrated lobu-lar or nest pattern,some with comedo necrosis.According to the degree of cell differentiation,it can be divided into high differentiation,medium differentiation,and low differentiation.Well differentiated sebocytes are round or polygonal large pale cells,with multivacuolated or bubbly cytoplasm and indentationed nuclei,nucleolis are visible;while poorly differentiated cells can resemble squamous cells,basal cells,and spindle cells.Immunohistochemical-ly,in all cases,PCK、EMA、P63、CK5/6 and BerEP4 are positive,CEA and AR are negative.Conclusion SC is rare and often misdiagnosed with squamous cell carcinoma or basal cell carcinoma.However,based on the typical histopathologic features and immunohistochemical reactions,the diagnosis can be more accurate.
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