摘要
目的 了解辽宁省阜新蒙古自治县农村地区≥35岁成年人血清亚精胺分布状况及影响因素,为进一步开展以血清亚精胺为线索的衰老相关疾病的干预措施提供理论支持.方法 于2019年6月至8月,采用分层整群随机抽样方法在中国辽宁省阜蒙县开展流行病学调查,选取年龄在≥35岁且无关键变量缺失的研究对象,采用高效液相色谱-荧光法(HPLC-FLD)检测血清亚精胺含量.采用SPSS 22.0软件进行统计分析,描述不同性别、年龄等人口学特征人群的血清亚精胺分布状况及其影响因素.结果 研究对象平均年龄为(59±10)岁,其中男性1 573名(35.76％),女性为2 826名(64.24％).研究对象血清亚精胺水平为24.8(13.4,50.1)ng/ml,男性35～44岁组和≥65岁组、饮酒、吸烟和超重者的血清亚精胺水平较高(P＜0.05).Spearman相关性分析结果显示,血清亚精胺水平与年龄、舒张压和体质指数呈正相关(r=0.044,0.046,0.051,P＜0.05),与高密度脂蛋白胆固醇呈负相关(r=-0.031,P＜0.05).结论 辽宁省农村地区≥35岁成人血清亚精胺的分布存在人群差异,且受到性别、年龄、体质指数及行为生活方式等因素的影响.同时,亚精胺与衰老及心血管疾病,尤其是脑卒中密切相关.
Abstract
Objective To understand the distribution characteristics and influencing factors of serum spermidine in adults aged ≥35 years in the rural areas of Fumeng county,Liaoning province.Therefore,it provides theoretical support for further intervention measures for aging-related diseases centered on serum spermidine.Methods From June 2019 to August 2019,stratified cluster random sampling was used to conduct an epidemiological investigation in Fumeng County,Liaoning Province,China.Subjects aged ≥ 35 years with no missing key variables were included.Spermidine levels in serum were measured using high-performance liquid chromatography with a fluorescence detector(HPLC-FLD).SPSS 22.0 software was used for statistical analysis to described the distribution and related factors of serum spermidine in populations with different gender,age and other demographic characteristics.Results In total,the mean Mean±SD age of participants was(59.2±10.0)years,including 1 573(35.76％)male and 2 826 females(64.24％).Serum spermidine levels showed a skewed distribution,with a median(quartile)of 24.8(13.4,50.1)ng/ml,and men,35～44 years and ≥65 years,drinkers,smokers,overweight population had higher spermidine levels,the differences were statistically significant(P＜0.05).The results of Spearman correlation analysis showed that serum spermidine levels were positively correlated with age,diastolic blood pressure(DBP),and body mass index(BMI)(P＜0.05),and negatively correlated with high density lipoprotein(HDL)(P＜0.05).Conclusion The distribution of serum spermidine in adults aged 35 and above in rural areas of Liaoning Province was different among different population groups,and was affected by gender,age,body mass index and behavior lifestyle.At the same time,spermidine is closely related to aging and cardiovascular diseases,especially stroke.
基金项目
国家自然科学基金面上项目(82073645)
吕梁市引进高层次科技人才重点研发项目(2022RC27)
维普
万方数据