Objective To explore the application value of contrast-enhanced ultrasound(UC)and CT enhanced scanning in the diagnosis of liver cancer.Methods One hundred and twenty-two patients with suspected liver cancer were randomly selected,and all patients underwent UC and CT enhanced scanning for diagnosis.At the same time,pathological screening was performed.The pathological examination results showed 100 cases of liver cancer and 22 cases of benign liver diseases.The sensitivity,specificity,and accuracy of different diagnostic methods were compared.Results The positive rates of CT enhanced scanning and UC diagnosis were the same,both of which were 74.6%(91/122).The positive detection rate of CT enhanced scanning combined with UC diagnosis was 79.5%(97/122),which was higher than that of the two separate detection methods(P<0.05).The sensitivity,specificity,positive/negative predictive value,and diagnostic accuracy of CT enhanced scanning+UC diagnosis were 96.0%,95.5%,99.0%,84.0%,and 95.9%,respectively,which were higher than those of CT enhanced scanning 81.0%,54.6%,89.0%,38.7%,and 76.2%(x2=11.054,9.818,8.452,11.729,19.684,P=0.001,0.002,0.004,0.001,<0.001),and were also higher than those of UC diagnosis 82.0%,59.1%,90.1%,41.9%and 77.9%(x2=0.010,8.282,7.317,10.266,17.408,P=0.002,0.004,0.007,0.001,<0.001).Conclusion The accuracy of UC combined with CT enhanced scanning in diagnosing liver cancer is high,and the sensitivity,specificity,and diagnostic accuracy of the combined diagnosis are high,which is worth promoting.