Objective To explore the serum IL-10 and TGF-β1 levels in patients with HPV infection and cervical lesions and their relationship with viral load.Methods Sixty patients diagnosed with HPV infection and cervical lesions in our hospital from March 2021 to June 2023 were retrospectively selected,and 50 female volunteers who underwent gynecological health examinations were included as the health group during the same period.The high-risk HPV DNA load,serum IL-10,and TGF-β,levels were measured.The relationship of IL-10 and TGF-β levels between cervical lesion severity and viral load was analyzed.Results The detection rates of high-risk HPV-DNA in the CIN Ⅲ group(73％)and cervical cancer group(92％)were significantly higher than those in the CIN Ⅰ group(33％)(x2=4.821,10.155,P=0.028,0.001).The detection rates of high-risk HPV-DNA in the cervical cancer group(92％)were higher than those in the CIN Ⅱ group(59％),with statistical significance(x2=4.224,P=0.039).For serum IL-10,TGF-β1 level,the cervical cancer group was higher than the CIN group and higher than the healthy group,and the differences between the groups were statistically significant(P＜0.05).Comparison within the CIN group showed that the higher the degree of precancerous lesions,the higher the serum levels of IL-10 and TGF in patients-β The higher the level,the statistically significant difference(P＜0.05).Serum IL-10 and TGF levels in patients with HPV infection and cervical lesions-β Compared at the 1st level,the HPV viral load of groups＞1 000,101～1 000,and 1～100 decreased sequentially,and the difference between the two comparison groups was statistically significant(F=25.494,7.539,P＜0.001).According to Spearman correlation analysis,the HPV-DNA viral load is related to serum IL-10 and TGF levels-β There was a significant positive correlation at all levels(r=0.461,0.172,P＜0.05).Conclusion Serum IL-10 and TGF-β1 level is related to the severity of cervical lesions,and their expression levels are positively correlated with HPV viral load.Detection of serum IL-10 and TGF-β1 has important reference value for evaluating the condition of cervical lesions.
Human papilomavirusCervical lesionsInterleukin-10Transforming growth factor-βViral load
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