Diagnostic value of combined detection of serum serum cystatin C,B-type natriuretic peptide,cardiac troponin Ⅰ and BChE in patients with acute myocardial infarction
Objective To investigate the expression and clinical significance of serum cystatin C(Cys-C),B-type natriuretic peptide(BNP),cardiac troponin I(cTnI),and butyrylcholinesterase(BChE)in acute myocardial infarction(AMI).Methods Total of 120 AMI patients admitted to our hospital from January 2021 to December 2022 were selected as the observation group,60 unstable angina patients admitted during the same period were selected as the control group,and 60 healthy individuals who underwent physical examination during the same period were selected as the health group.All study subjects were subjected to blood sampling for detection of Cys-C,BNP,cTnI and BChE levels,and the differences in Cys-C,BNP,cTnI and BChE among the three groups were compared.We also compared the differences in serum Cys-C,BNP,cTnI,and BChE levels among Killip grade Ⅰ,Ⅱ,and Ⅲ patients.ROC curves were used to analyze the clinical value of Cys-C,BNP,cTnI,BChE and combined detection in diagnosing AMI.Results The levels of Cys-C,BNP and cTnI in the observation group were(1.57±0.19)mg/L,(418±26)pg/ml,and(1.35±0.22)µg/L,respectively,higher than the control group[(0.98± 0.14)mg/L,(152±14)pg/ml,(0.42±0.08)μg/L],healthy group[(0.65±0.11)mg/L,(89±7)pg/ml,(0.24±0.03)μg/L],the BChE level was(6.4±1.0)kU/L,lower than the control group(12.4±1.2)kU/L and the healthy group(20.2±1.4)kU/L,with statistically significant differences(F=720.057,6 778.287,1 213.580,2 655.764,P＜0.05).The serum levels of Cys-C,BNP,and cTnI in Killip Ⅲ patients were(2.02±0.24)mg/L,(586±31)pg/ml,and(1.89±0.28)μg/L,respectively,higher than Grade Ⅱ[(1.52±0.18)mg/L,(416±25)pg/ml,(1.32±0.21)μg/L],GradeⅠ patients[(1.22± 0.14)mg/L,(305±22)pg/ml,(0.95±0.14)μg/L],the BChE level was(4.9±0.9)kU/L,lower than that of grade Ⅱ(6.6± 1.1)kU/L and grade Ⅰ patients(8.0±1.1)kU/L,with statistically significant differences(F=172.404,1 080.093,185.790,83.699,P＜0.05).ROC curves shows that the areas under the curves for Cys-C,BNP,cTnI,BChE and combined detection for diagnosing AMI are 0.803,0.818,0.838,0.835 and 0.954,respectively,indicating a higher value for combined detection.Conclusion Serum Cys-C,BNP,cTnI and BChE are all abnormally expressed in AMI patients,which is helpful for early diagnosis of the disease,and combined detection has higher diagnostic value.
维普
万方数据
