首页|以增强CT检查为基础胰腺导管腺癌肝转移相关预测模型研究

以增强CT检查为基础胰腺导管腺癌肝转移相关预测模型研究

Research on prediction models for liver metastasis of pancreatic ductal adenocarcinoma based on enhanced CT examination

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目的 探讨以增强CT检查为基础胰腺导管腺癌肝转移相关预测模型的价值.方法 选取江苏省盱眙县人民医院2019年1月至2023年6月期间收治的70例胰腺导管腺癌患者,入院后采用增强CT扫描,按病理检查将患者分为肝转移组及非转移组,测量2组患者肿瘤最大直径,比较2组动脉期、静脉期及延迟期CT值;同时获取2组CT扫描特征,比较2组CT扫描参数差异.结果 2组患者肿瘤最大直径及动脉期、静脉期、延迟期CT值比较差异无统计学意义(P>0.05),而肝转移组的肿瘤与动脉血管的最大夹角(T/A)、肿瘤与静脉血管的最大夹角(T/V)、肿瘤与肠系膜上静脉夹角均低于非转移组,肿瘤与动脉血管最小距离(TA)、肿瘤与静脉血管的最小距离(TV)均短于非转移组(P<0.05).肝转移组瘤周脂肪间隙模糊率、淋巴结肿大率均高于非转移组(P<0.05),肝转移组癌胚抗原、糖类抗原(CA)125、CA199水平均高于非转移组(P<0.05).在构建预测模型后,经绘制受试者工作特征(ROC)曲线,瘤周脂肪间隙模糊、TV距离、CA125对预测患者肝转移均有一定价值,其中联合指标更具预测价值(P<0.05).结论 构建以增强CT检查为基础胰腺导管腺癌肝转移的预测模型,能够有效预测肝转移,值得临床应用.
Objective To analyze the prediction model for liver metastasis of pancreatic ductal adenocarcinoma based on enhanced CT examination.Methods Seventy patients with pancreatic ductal adenocarcinoma treated in Xuyi County People's Hospital of Jiangsu Province from January 2019 to June 2023 were selected Nanjing from January 2019 to June 2023 were selected.After admission,enhanced CT scans were performed,and the patients were divided into liver metastasis group and non-metastasis group according to pathological examination.The maximum diameter of the tumor in the two groups was measured,and the CT values in the arterial,venous,and delayed phases were compared between the two groups.We simultaneously obtained two sets of CT scan features and compared the differences in CT scan parameters between the two sets.Results There was no significant difference(P>0.05)in the maximum diameter of tumors and CT values of arterial,venous,and delayed phases between the two groups of patients.However,in the liver metastasis group,the maximum angle between tumor and arterial(T/A),the maximum angle between tumor and venous(T/V),and the angle between tumor and superior mesenteric vein were lower than those in the non-metastasis group.The minimum distance between tumor and arterial(TA)and the minimum distance between tumor and venous vessels(TV)were shorter than those of the non-metastasis group(P<0.05).The blurring rate of peritumoral fat space and lymph node enlargement rate in the liver metastasis group were higher than those in the non-metastasis group(P<0.05),and the levels of CEA,CA125,and CA199 in the liver metastasis group were higher than those in the non metastasis group(P<0.05).After constructing the prediction model,the ROC curve was plotted,and the fuzzy peritumoral fat gap,TV distance,and CA125 had certain value in predicting liver metastasis in patients.Among them,the combined indicators had more predictive value(P<0.05).Conclusion Constructing a prediction model for liver metastasis of pancreatic ductal adenocarcinoma based on enhanced CT examination can effectively predict liver metastasis and is worthy of clinical application.

Pancreatic intraductal neoplasmsNeoplasm metastasisTomography,X-ray computerLiver

孟晓峰、谷华杰、沈阳、周正

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盱眙县人民医院医学影像科,盱眙 211700

胰腺导管内肿瘤 肿瘤转移 体层摄影术,X线计算机

2024

实用医技杂志
山西医药卫生传媒集团有限责任公司

实用医技杂志

影响因子:0.534
ISSN:1671-5098
年,卷(期):2024.31(4)