Objective To observe the value of combining multi-slice spiral computed tomography(MSCT)combined with enhanced scanning in the differential diagnosis of pulmonary space occupying lesions,in order to improve the detection of clinical pulmonary space occupying lesions and provide scientific imaging references for guiding clinical diagnosis and treatment.Methods The research subjects were selected from 100 patients with pulmonary space occupying lesions who were admitted to our hospital from October 2021 to October 2022 were selected as the research subjects.All patients underwent pathological tissue,MSCT,and enhanced scanning examinations.The pathological tissue examination results were used as the gold standard to analyze the value of MSCT and enhanced scanning alone and in combination for the differential diagnosis of pulmonary space occupying lesions.Results All patients with pulmonary space occupying lesions received accurate pathological diagnosis.Among the 100 patients included,13 were benign nodules,and the remaining 87 were malignant.The results of MSCT examination showed that there was no statistically significant difference between benign and malignant in satellite lesion detection(P>0.05).Malignant space occupying lesions were characterized by nodule diameter(≥1.0 cm),ground-glass like features,irregular morphology,rough boundaries,and pleural depression.The proportion of bronchovascular bundle sign was higher than that of benign space occupying lesions(P<0.05).MSCT detected 83 cases of malignant and 17 cases of benign lung masses in 100 cases,with diagnostic efficacy of sensitivity of 92.0%,specificity of 76.9%,accuracy of 90.0%,positive predictive value of 96.4%,and negative predictive value of 58.8%.Enhanced scanning detected 80 cases of malignancy and 20 cases of benign,with diagnostic efficacy of sensitivity of 89.7%,specificity of 84.6%,accuracy of 89.0%,positive predictive value of 97.5%,and negative predictive value of 55.0%.MSCT combined with enhanced scanning detected 85 cases of malignancy and 15 cases of benign,with diagnostic efficacy of sensitivity of 96.6%,specificity of 92.3%,accuracy of 96.0%,positive predictive value of 98.8%,and negative predictive value of 80.0%.The ROC curve graph was used and the results show that the area under the curve for MSCT diagnosis of pulmonary space occupying lesions is AUC(95%CI)=0.871(0.705,0.984),the enhanced scan is AUC(95%CI)=0.844(0.751,0.991),and the combined diagnosis is AUC(95%CI)=0.944(0.857,1.000).The combined diagnosis has the highest AUC,indicating greater more diagnostic value compared to individual imaging modalities.Conclusion The combination of MSCT and enhanced scanning in the diagnosis of pulmonary space occupying lesions has more diagnostic value and is conducive to improving the detection rate of cancerous lesions in pulmonary space occupying lesions.