Study on the relationship between intercellular adhesion molecule-1 expression in alveolar lavage fluid of mycoplasma pneumoniae and mucus thrombus formation in children
Objective To investigate the relationship between the expression of intercellular adhesion molecule-1(ICAM-1)in alveolar lavage fluid of mycoplasma pneumoniae and the formation of pneumonia mucus plugs in children.Methods Eighty children with pediatric mycoplasma pneumoniae(MPP)hospitalized in our hospital between August 2022 and November 2023 were selected for this study.These 80 children were divided into the study group(the mucus plug group,55 cases)and the control group(the non-mucus plug group,25 cases)according to the characteristics of mucus secretion under tracheoscopy,and the relationship between ICAM-1 expression and the formation of mucus plugs in pneumonia was analyzed.Results The levels of WBC,N,CRP,LDH,and ICAM-1 in the study group were higher than those in the control group(P＜0.05);Multifactorial logistic regression analysis showed that WBC,N,CRP,LDH,and ICAM-1 were independent influences affecting the formation of mucus plugs in pneumonia(P＜0.05).The levels of ICAM-1 in the alveolar lavage fluid of the study group were related to WBC,N,CRP,and LDH were positively correlated(P＜0.05).Conclusion The more severe the disease in children with MPP,the stronger the inflammatory response in the children's bodies,and the effect of the expression level of ICAM-1 on the process of inflammatory response in children with MPP is significant.When its concentration is elevated,it may lead to the formation of pneumonia mucus plugs.
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