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脑出血患者预后不良的logistic回归影响因素分析

Logistic regression analysis of influencing factors of poor prognosis in patients with hemorrhagic stroke

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目的 探讨脑出血患者预后不良的危险因素,旨在为临床治疗提供指导.方法 在我院2020年6月至2023年6月收治的脑出血患者中,基于纳入、排除标准收集符合研究条件的80例患者资料,进行分析回顾性研究,收集患者一般资料、影像学资料、实验室检查指标以及改良Rankin量表(mRS)评估的预后情况,根据患者预后情况分为预后良好组和预后不良组,比较2组患者一般资料、实验室检查等情况,采用logistic回归分析患者预后不良的危险因素.结果 80例出血性脑卒中患者预后不良率为45.0%;经logistic 回归分析,年龄≥60 岁[OR(95%CI):2.204(1.064,3.849),P=0.016]、合并高血压[OR(95%CI):1.815(1.285,2.562),P=0.001]、合并糖尿病[OR(95%CI):2.266(1.020,5.032),P=0.022]、格拉斯哥昏迷(GCS)评分<91 分[OR(95%CI)=3.330(2.044,5.425),P=0.000]、美国国立卫生院脑卒中量表(NIHSS)评分>15 分[OR(95%CI)=2.219(1.216,4.050),P=0.005]、破入脑室[OR(95%CI)=2.349(1.300,4.246),P=0.002]、出血量≥30 ml[OR(95%CI)=2.160(1.211,3.850),P=0.005]、残余血肿体积≥15 ml[OR(95%CI)=2.568(1.396,4.724):P=0.005]、C 反应蛋白(CRP)升高[OR(95%CI)=2.784(1.424,5.443),P=0.001]、白细胞计数(WBC)升高[OR(95%CI)=6.141(1.246,30.279),P=0.013]以及 肾小球滤过率(GFR)[OR(95%CI)=2.286(1.010,5.177),P=0.024]水平是影响患者预后的危险因素.结论 脑出血患者预后主要与年龄、合并高血压或糖尿病史、GCS与NIHSS评分、存在破入脑室、出血量和残余血肿体积较大、炎症水平以及GFR水平有关,临床可基于危险因素对患者预后进行预测,可为患者个体化管理提供依据.
Objective To investigate the risk factors of poor prognosis in patients with hemorrhagic stroke,in order to provide guidance for better clinical treatment.Methods Among the patients with hemorrhagic stroke admitted to the hospital from June 2020 to June 2023,the data of 80 patients eligible for the study were collected based on the inclusion and exclusion criteria for retrospective analysis,and the general data,imaging data,laboratory examination indicators and prognosis assessed by the modified ranking scale(mRS)were collected.Patients were divided into good prognosis group and poor prognosis group according to their prognosis.The general data distribution and laboratory test results of the two groups were compared,and the risk factors for poor prognosis were analyzed by logistic regression.Results The poor prognosis rate of 80 patients with hemorrhagic stroke was 45.0%.Logistic regression analysis,age 60 or more[OR(95%CI)=2.204(1.064,3.849),P=0.016],hypertension[OR(95%CI)=1.815(1.285,2.562),P=0.001],diabetes mellitus[OR(95%CI)=2.266(1.020,5.032),P=0.022],Glasgow coma score(GCS)<91[OR(95%CI)=3.330(2.044,5.425),P=0.000],NIHSS score>15 points[OR(95%CI)=2.219(1.216,4.050),P=0.005],broken into the ventricle[OR(95%CI)=2.349(1.300,4.246),P=0.002],the bleeding ≥ 30 ml[OR(95%CI)=2.160(1.211,3.850),P=0.005],the residual hematoma volume ≥ 15 ml[OR(95%CI)=2.568(1.396,4.724),P=0.005),elevated C-reactive protein(CRP)[OR(95%CI)=2.784(1.424,5.443),P=0.001],white blood cell count(WBC)increased[OR(95%CI)=6.141(1.246,30.279),P=0.013]and the level of glomerular filtration rate(GFR)[OR(95%CI)=2.286(1.010,5.177),P=0.024]were risk factors affecting the prognosis of patients.Conclusion The prognosis of patients with hemorrhagic stroke is mainly related to age,history of combined hypertension or diabetes,GCS and NIHSS scores,presence of ventricle rupture,large volume of blood loss and residual hematoma,inflammation level and GFR level.The prognosis of patients can be predicted based on clinical risk factors,which can provide basis for individual management of patients.

Intracerebral hemorrhagePrognosisRisk factor analysis

王宁

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郑州市第二人民医院神经外科,郑州 450000

脑出血 预后 危险因素分析

2024

实用医技杂志
山西医药卫生传媒集团有限责任公司

实用医技杂志

影响因子:0.534
ISSN:1671-5098
年,卷(期):2024.31(5)
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