Comparison of efficacy and toxicity reactions between sequential chemoradiotherapy and concomitant chemoradiotherapy in patients with non-surgically resectable non-small cell lung cancer
Objective Sequential chemoradiotherapy and synchronous chemoradiotherapy were administered to patients with non-surgically resectable non-small cell lung cancer to compare the clinical effects of the two treatment regimens.Methods The subjects of this study were 80 patients with non-surgically resectable non-small cell lung cancer,who were admitted to the hospital from January 2020 to August 2022.The 80 patients were divided into a control group with 40 cases and an observation group according to the method of numerical tables,and the treatment plan of the former was sequential chemoradiotherapy and that of the latter was synchronous chemoradiotherapy.The levels of serum tumor markers were compared between the two groups before and after the treatment,and the near-term therapeutic efficacy of the patients of the two groups was evaluated by the size of the lesions,and the incidence of toxic reactions of the two groups was also recorded in the course of the treatment.Results After radiotherapy,the levels of serum tumor markers[glycan antigen 125(CA125)∶(38.9±3.4)U/ml vs(42.1±6.7)U/ml,t=2.982,P=0.004;squamous epithelial cell carcinoma antigen(SCC-Ag)∶(0.31±0.081)ng/ml vs(0.38±0.12)ng/ml,t=2.914,P=0.005;cytokeratin 19 fragment antigen 21-1(CYFRA21-1)(20.2±3.2)ng/ml vs(17.0±1.6)ng/ml,t=2.430,P=0.017]of the observation group were lower than those of the control group(P＜0.05).the disease remission rate and control rate of the observation group were 75.0％(30/40)and 95.0％(38/40),respectively,while those of the control group were 50.0％(20/40)and 77.5％(31/40),respectively,and the difference between the two groups was significant(x2=4.381,P=0.036;x2=5.165,P=0.023).Toxic reactions in the observation group were slightly higher than those in the control group,but there was no significant difference in the occurrence of radiation esophagitis,gastrointestinal reactions,radiation pneumonitis,and bone marrow suppression between the two groups(P＞0.05).Conclusion Synchronous chemoradiotherapy is more effective than sequential chemoradiotherapy in controlling serum tumor marker levels in patients with non-surgically resectable non-small cell lung cancer,and synchronous chemoradiotherapy enhances the near-term outcome of patients without increasing toxicity
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