Objective To evaluate the value of combined plasma D-dimer,PCT(procalcitonin)and interleukin-6(IL-6)tests in the diagnosis of Group B Streptococcus(GBS)infection in pregnant women in late pregnancy.Methods Forty-two GBS-positive pregnant women in late pregnancy were collected as an experimental group and 30 GBS-negative pregnant women as a control group from September 2021 to September 2022.All participants were tested for plasma D-dimer,PCT and IL-6 levels.Results The differences between the experimental and control groups in terms of age and gestational weeks were not significant(P＞0.05).Plasma D-dimer(0.89±0.15)mg/L,PCT(0.085±0.010)ng/ml,and IL-6(18.8±2.1)pg/ml levels were significantly higher in the experimental group than those in the control group[D-dimer:(0.54±0.11)mg/L,PCT:(0.039±0.005)ng/ml,IL-6:(9.7±0.8)pg/ml,all P＜0.01].The sensitivity of plasma D-dimer,PCT and IL-6 assays was 76.2％,80.9％and 83.3％,respectively,and the specificity was 36.7％,40.0％and 36.7％,respectively.The combined assay showed higher comprehensive performance and improved diagnostic sensitivity,specificity and the positive value for GBS infection was 92.9％、56.7％vs 75.0％.Conclusion This study demonstrated that the combined assay of plasma D-dimer,PCT and IL-6 showed significant diagnostic value in the diagnosis of maternal GBS infection with statistical significance.The combined use of these biochemical indicators may improve diagnostic accuracy,provide more precise clinical management and intervention for pregnant women,and help optimize health management strategies for pregnant women and newborns.
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