A study on the correlation between anti-müllerian hormone and pregnancy outcomes in elderly infertile women undergoing assisted reproductive technology
Objective To explore the correlation between anti-mullerian hormone and pregnancy outcomes in elderly infertile women undergoing assisted reproductive technology.Methods A retrospective analysis was conducted on the clinical data of 239 cycles of patients who received assisted reproductive technology at the Reproductive Medicine Center of our hospital from January 2019 to December 2022.Based on the age of the patients,including the low advanced-age group(35-37 years,125 cycles),the mid advanced-age group(38-40 years,84 cycles),and the very advanced-age group(≥ 41 years,30 cycles),the basic information of the three groups of patients,the correlation between anti-Mullerian hormone and pregnancy outcomes were compared and analyzed.The predictive value of anti-Mullerian hormone on pregnancy outcomes through logistic regression analysis.Results There was no statistically significant difference in body mass index,infertility type,basal FSH level,and basal LH level among the three groups of patients(P＞0.05).The levels of AMH in the low and mid advanced-age groups were compared with those in the very advanced-age age group,and the differences were statistically significant(P＜0.05),but there was no difference between the low and mid advanced-age groups(P＞0.05).The Gn initiation dose of three groups of patients showed an increasing trend,and there was a statistically significant difference(P＜0.05)among the low,mid and very advanced-age group,respectively.However,there was no difference(P＞0.05)between the mid and the very advanced-age group.There was no statistically significant difference in the total amount of Gn and Gn days(P＞0.05).The number of retrieved eggs,excellent embryos,and available embryos in the three groups of patients showed a decreasing trend.We compared the number of eggs obtained in three groups,there was a higher number of eggs in the low advanced-age group than the mid advanced-age group and the very advanced-age group.The mid advanced-age had a higher number of eggs than the very advanced-age group.However,there was no significant difference in the number of embryos available between the low advanced-age groups,with only a statistically significant difference(P＜0.05).The clinical pregnancy rate and/or birth rate decrease with age,but there is no difference between the low and the mid advanced-age group,or between the mid and the very advanced-age group.The difference between the low and the very advanced-age group is significant(P＜0.05).The overall trend of the number of retrieved eggs,excellent embryos,and available embryos in the three groups of patients is positively correlated with AMH levels,with the highest correlation observed in the elderly group.There is no correlation between clinical pregnancy rate and live birth rate and AMH levels.Anti-Mullerian hormone cannot serve as an independent influencing factor on pregnancy outcomes in elderly infertile women undergoing assisted reproductive technology.Conclusion Serum levels of anti-Mullerian hormone decrease with age and are significantly correlated with the number of retrieved eggs,optimal embryos,and available embryos.But it cannot predict the clinical pregnancy rate and live birth rate of elderly infertile women undergoing assisted reproductive assistance.
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