人乳头状瘤病毒基因分型检测在宫颈病变中的应用价值
Application value of HPV genotyping detection in cervical lesions
李秋平 1揭雅萍 1刘云1
作者信息
- 1. 江西省赣州市石城县妇幼保健院检验科,赣州 342706
- 折叠
摘要
目的 分析人乳头瘤状病毒(HPV)基因分型检测在宫颈病变中的应用价值.方法 回顾性分析2021年1月至2023年12月3 760例进行宫颈病变筛查且HPV阳性女性的临床资料,受检女性均进行HPV基因分型检测与液基细胞学检测(TCT)检测,以宫颈活检病理组织学为金标准,确诊68例存在宫颈病变[宫颈上皮内瘤变(CIN Ⅰ～Ⅲ:65例;癌变:3例].分析HPV阳性率;HPV基因分型分布情况;不同宫颈病变者高危型HPV及TCT检查情况.结果 HPV单一感染占比较大,为73.99％(2 782/3 760),高危型感染占 73.94％(2 780/3 760),低危型感染占 0.05％(2/3 760);HPV 52+其他分型、HPV 53+其他分型、HPV58+其他分型为最主要的HPV多重感染类型;HPV基因分型检查对宫颈病变的检出率高于TCT检查,差异有统计学意义(P＜0.05).结论 HPV基因分型检测有助于了解患者HPV感染情况,对宫颈病变具有较高的临床辅助检查价值.
Abstract
Objective To analyze the application value of human papillomavirus(HPV)genotyping detection in cervical lesions.Methods The clinical data of 3 760 women who underwent cervical lesion screening and were HPV positive from January 2021 to December 2023 were retrospectively analyzed.All the women underwent HPV genotyping and liquid based cytology test(TCT).As a pathological examination,cervical biopsy pathology was taken as the gold standard,68 cases were confirmed to have cervical lesions(CIN Ⅰ～Ⅲ:65 cases;canceration:3 cases).The positive rate of HPV,HPV genotyping distribution,high risk HPV and TCT examination in patients with different cervical lesions were analyzed.Results HPV single infection accounted for 73.99％(2 782/3 760),high-risk infection accounted for 73.94％(2 780/3 760),low-risk infection accounted for 0.05％(2/3 760).HPV 52+other subtypes,HPV 53+other subtypes and HPV-58+other subtypes were the main types of HPV multiple infection.The detection rate of HPV genotyping for cervical lesions was higher than that of TCT,and the difference was statistically significant(P＜0.05).Conclusion HPV genotyping test is helpful to understand the HPV infection situation of patients,and has high clinical auxiliary examination value for cervical lesions.
关键词
宫颈疾病/宫颈肿瘤/人乳头瘤状病毒/基因分型技术Key words
Uterine cervical diseases/Uterine cervical neoplasms/Human papilloma virus/Genotyping techniques引用本文复制引用
出版年
2024
NETL
NSTL
万方数据