Objective To analyze the diagnostic efficacy of magnetic resonance imaging(MRI)enhanced scanning and multi-slice spiral CT(MSCT)in primary liver cancer(HCC).Methods This study is a retrospective study,with 108 patients who underwent liver imaging examinations at the First Affiliated Hospital of Henan University of Science and Technology from January 2022 to December 2022 as the research subjects.Based on the pathological diagnosis results,48 patients with HCC were classified as the malignant group,and 60 patients with hepatic hemangioma were classified as the benign group.Both groups underwent MRI enhanced scanning and MSCT scanning,and the diagnostic efficacy of different imaging methods for liver tumors was compared.The features of HCC lesion enhancement were analyzed.Results The diagnostic accuracy,sensitivity and specificity of MSCT+MRI for HCC were 95.4%(103/108),95.8%(46/48)and 95.0%(57/60),respectively.These were higher than that of single MRI examination[80.7%(87/108),83.3%(40/48),78.3%(47/60)]and single MSCT examination[71.3%(77/108),72.9%(35/48),70.0%(42/60)].The difference was statistically significant(P<0.05).Imaging features showed that HCC lesions were large in diameter,irregular in shape,with clear tumor boundaries,low signal on T1WI and high signal on T2WI,often accompanied by pleural effusion and abdominal thickening,and peripheral tissue invasion.High density signal intensification was evident in the arterial stage,low density signal intensification in the portal vein stage,and low density signal intensification in the delayed stage,mainly characterized by rapid rise and rapid decline.Conclusion Both MSCT and MRI enhanced scanning can effectively diagnose HCC.The diagnostic accuracy,sensitivity and specificity of MSCT combined with MRI enhancement are higher.