Objective To investigate the clinical value of high frequency ultrasound combined with serum thyrotropin(TSH),total triiodothyronine(TT3)and total thyroxine(TT4)in the diagnosis of benign and malignant thyroid nodules.Methods A retrospective analysis was conducted on 156 patients with thyroid nodules admitted to our hospital from January 2021 to December 2022,and were divided into benign group(96 cases)and malignant group(60 cases)according to the postoperative pathology.Preoperative serum(TSH,TT3 and TT4)and high frequency ultrasound were performed in 156 patients with thyroid nodules.The parameters of high frequency ultrasound(minimum diastolic blood flow velocity,pulsation index and resistance index)and serum level(TSH level,TT3 level and TT4 level)were compared.Results There were significant differences in boundary condition,calcification and halo,blood flow signal,minimum diastolic blood flow velocity,pulsation index,resistance index and serum level(TSH、TT3、TT4)between the two groups(P＜0.05).The results showed that microcalcification,acoustic halo,blood flow signal above level 1,high frequency ultrasound parameters(minimum diastolic blood flow velocity,pulsation index and resistance index)and serum level(TSH、TT3、TT4)were independent factors of nodule malignancy in patients with thyroid nodules.High frequency ultrasound combined with serum TSH,TT3 and TT4 levels was used to diagnose malignant thyroid nodules.The AUC of ROC(95％CI)was 0.965(0.941,0.989),and the differentiation was good.The Yoden value,sensitivity and specificity of the model was approximately 0.791,0.833 and 0.958,respectively.Conclusions Microcalcification,halo,blood flow signal above level 1,high frequency ultrasound parameters and serum level are the risk factors of nodule malignancy in patients with thyroid nodules.
关键词
甲状腺结节/高频超声/促甲状腺激素/总三碘甲状腺原氨酸/总甲状腺素/临床价值
Key words
Thyroid nodules/High-frequency ultrasound/Thyrotropin/Total triiodothyronine/Total thyroxine/Clinical value
万方数据