Objective To analyze the clinical and imaging features of patients with multi-drug resistant pulmonary tuberculosis,and to explore its influencing factors.Methods Pulmonary tuberculosis patients hospitalized in the Fourth People's Hospital of Lianyungang City,Jiangsu Province from June 2022 to January 2024 were collected as the research subjects.According to the results of drug sensitivity test,they were divided into drug-resistant group and sensitive group.The demographic data,clinical characteristics,laboratory examination and imaging characteristics of the two groups were compared,and the influencing factors of drug-resistant pulmonary tuberculosis infection were analyzed by binomial multivariate logistic analysis.Results Among the 110 patients with pulmonary tuberculosis,50 were drug-resistant tuberculosis and 60 were drug-sensitive.The analysis of clinical characteristics showed that the proportion of retreatment and chronic obstructive pulmonary disease in the drug-resistant group was higher than that in the sensitive group,and the difference was statistically significant(P＜0.05).CT image analysis showed that the cavity and bronchiectasis in the drug-resistant group were more common than those in the sensitive group,while the incidence of tree bud sign in the sensitive group was higher than that in the drug-resistant group,and the differences were statistically significant(P＜0.05).Binary logistic regression analysis showed that cavity[OR(95％CI)=4.726(2.044,10.927),P＜0.05]and chronic obstructive pulmonary disease[OR(95％CI)=2.888(1.012,8.244),P＜0.05]were risk factors for drug resistance of pulmonary tuberculosis.Conclusion Patients with chronic obstructive pulmonary disease and cavitary pulmonary tuberculosis are risk factors for drug resistance to tuberculosis.Clinically,it is necessary to supervise the whole process and implement personalized treatment programs to improve the cure rate of multi-drug resistant tuberculosis.
维普
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