The value of peripheral blood neutrophil to lymphocyte ratio combined with C-reactive protein to prealumin ratio in the early diagnosis of influenza A in adults
The value of peripheral blood neutrophil to lymphocyte ratio combined with C-reactive protein to prealumin ratio in the early diagnosis of influenza A in adults
Objective To investigate the diagnostic value of peripheral blood neutrophil/lymphocyte ratio(NLR)and CRP/PA ratio in the early stage of adult influenza A patients.Methods Thirty-four patients tested for influenza A positive antigen diagnostic reagent(colloidal gold)from January 2022 to January 2024.Thirty-two patients negative for all H 1 x antigen were used as control group.The NLR and CRP/PA ratio were detected by the fully automatic blood cell analyzer and the fully automatic biochemical analyzer.The variability of the NLR and CRP/PA ratios between the two groups was analyzed.The receiver operating characteristic(ROC)curve was used to predict the value of NLR and CRP/PA ratio in early prediction diagnosis.Results The mean NLR of the control group was(3.42±1.85).The mean value of and CRP/PA ratio is(0.03±0.03);the mean NLR of the group was(6.23±3.10),and the mean of CRP/PA ratio was(0.15±0.13);the NLR and CRP/PA ratio in the first flu group were higher than the control group,significant(t=4.485,5.120,P＜0.05).The ROC curve area(95％CI)for NLR diagnosis of influenza A was 0.776(0.666,0.888)with a cutoff of 5.12,sensitivity of 0.65 and specificity of 0.84.The curve area(95％CI)of the CRP/PA ratio to diagnose influenza A was 0.874(0.794,0.954),with a cutoff of 0.04,a sensitivity of 0.94,and a specificity of 0.66.The ROC curve area(95％CI)for NLR combined with CRP/PA ratio was 0.928(0.862,0.994),sensitivity was 0.82 and specificity 0.99.Conclusion Both NLR and CRP/PA ratio can be used as biomarkers for independent prediction of influenza A.The combined detection of NLR and CRP/PA ratio is greater in the early prediction and diagnosis of influenza A in adults,and plays a positive role in the early treatment of influenza a flu patients.
关键词
C反应蛋白质/前白蛋白/中性粒细胞/淋巴细胞比值/甲型流感/诊断价值
Key words
C-reactive protein/Prealbumin/Neutrophil to lymphocyte ratio/Influenza A/Diagnostic value
维普
万方数据