Objective To explore the relationship between serum Interleukin-6,C-reactive protein,procalcitonin and the degree of acute lung injury in elderly patients with sepsis.Methods A total of 100 elderly patients with acute lung injury caused by sepsis from January 2023 to December 2023(observation group)were selected,and another 100 healthy volunteers from the physical examination department(health group)were selected.Blood samples were collected,serum IL-6,CRP,PCT were tested,and lung ultrasound examination was performed.Results Compared with the healthy group,the serum levels of IL-6,CRP,and PCT in the observation group were significantly increased,with statistical significance(P<0.05).As the condition worsens,the levels of serum IL-6,CRP,and PCT significantly increase,and there is a statistically significant difference in pairwise comparison between each indicator group(P<0.05).Pearson correlation analysis showed that serum IL-6,CRP,PCT levels were positively correlated with lung ultrasound scores in elderly patients with acute lung injury caused by sepsis(r=0.85,0.43,0.76,P<0.01).Conclusion Serum IL-6,CRP,and PCT are closely related to the severity of acute lung injury in elderly sepsis patients,and their elevated levels can serve as potential indicators for evaluating the degree of lung injury in patients.