Objective To investigate the relationship between contrast-enhanced ultrasound features and renal histopathological changes in a rabbit model of renal artery stenosis.Methods A total of 96 healthy New Zealand rabbits were selected and different degrees of rabbit renal artery stenosis models were established using the intrathecal renal artery wall compression method.According to the time points of the modeling surgery,they were divided into two subgroups,T2 and T7.Each subgroup was further divided into a control group,a sham operation group,an extremely mild group,a mild group,a moderate group,and a severe group,with 8 rabbits in each subgroup.On the 2nd and 7th days after modeling,the two subgroups of animal models were subjected to contrast-enhanced ultrasound examination,blood creatinine and blood urea nitrogen detection,respectively.Jablonski method was used for pathological quantitative scoring of renal tubular injury.We analyzed the correlation between renal cortical contrast-enhanced ultrasound parameters and pathological scoring of renal tubular injury.Results Compared with the 2nd day after modeling of renal artery stenosis,the pathological scores of renal tubular injury increased in the moderate and severe groups on the 7th day after modeling(both P＜0.05).The Pearson correlation analysis results showed that on the 7th day after modeling renal artery stenosis,the renal cortical ultrasound parameters TTP,serum creatinine,and blood urea nitrogen were positively correlated with the pathological score of renal tubular injury(r=0.82,0.77,0.700,P＜0.05).The renal cortical ultrasound parameters WIS,PI and AUC were negatively correlated with the pathological score of renal tubular injury(r=-0.62,-0.81,-0.68,P＜0.05).Conclusion Contrast enhanced ultrasound is an effective diagnostic method for evaluating renal cortical blood flow perfusion and renal tissue pathological damage after renal artery stenosis.
万方数据
维普
