摘要
目的 探讨妊娠期贫血患者血常规检测指标与不良妊娠结局的关系.方法 选取2021年1月至2023年1月医院收治的150例妊娠期贫血患者作为研究对象并设为研究组.将研究组妊娠期贫血患者根据不同妊娠阶段分为孕早期(34例)、孕中期(72例)、孕晚期(44例),根据检测结果判断患者的贫血严重程度、贫血类型,比较不同孕周患者的贫血严重程度及贫血类型.另选取同期在该院接受检查的健康孕妇150名为对照组,对比2组间及不同孕期期间血常规[血红蛋白(Hb)、红细胞计数(RBC)、红细胞平均血红蛋白含量(MCH)、血细胞分布宽(RDW)、红细胞平均体积(MCV)、血细胞平均血红蛋白浓度(MCHC)]水平.收集对照组与研究组的不良妊娠结局,采用Pearson法分析血常规检测指标与不良妊娠结局的相关性.结果 随着孕期改变,中度贫血的占比显著升高.不同妊娠阶段贫血严重程度分布情况比较,差异有统计学意义(P＜0.05);早期及孕中期多为小细胞贫血,孕晚期多为大细胞贫血.不同妊娠阶段大、小细胞贫血孕妇分布情况比较,差异有统计学意义(P＜0.05).研究组妊娠贫血患者的RBC、Hb、HCT、MCV、MCH、MCHC均显著低于对照组,而RDW则显著高于对照组(P＜0.05).孕晚期妊娠贫血患者的RBC、Hb、HCT、MCV、MCH、MCHC均显著低于孕中期与孕早期,而RDW则显著高于孕中期与孕早期(P＜0.05);研究组不良妊娠结局发生率高于对照组(P＜0.05).Pearson相关分析得知,RBC、Hb、HCT、MCV、MCH、MCHC与不良妊娠结局为正相关(r=0.694、0.722、0.633、0.747、0.652、0.732,P均＜0.05);而 RDW 与不良妊娠结局为负相关(r=-0.835,P＜0.05).孕早期组Pearson相关分析结果显示:RBC、Hb、HCT、MCV、MCH、MCHC与不良妊娠结局为正相关(r=0.616、0.549、0.715、0.627、0.571、0.592,P均＜0.05);而 RDW 与不良妊娠结局为负相关(r=-0.710,P＜0.05).孕中期组Pearson相关分析结果显示:RBC、Hb、HCT、MCV、MCH、MCHC与不良妊娠结局为正相关(r=0.551、0.521、0.619、0.571、0.492、0.621,P均＜0.05);而 RDW 与不良妊娠结局为负相关(r=-0.741,P＜0.05);孕晚期组Pearson相关分析结果显示:RBC、Hb、HCT、MCV、MCH、MCHC与不良妊娠结局为正相关(r=0.694、0.691、0.549、0.427、0.672、0.711,P均＜0.05);而RDW与不良妊娠结局为负相关(r=-0.552,P＜0.05).结论 妊娠期贫血妇女血常规检测指标与正常妊娠期妇女比较水平显著降低,不同孕期血常规治疗水平也存在显著差异,同时常规治疗与不良妊娠结局存在相关性.
Abstract
Objective To explore the relationship between blood routine test indicators and adverse pregnancy outcomes in women with gestational anemia.Methods A total of 150 pregnant women with anemia admitted to the hospital from January 2021 to January 2023 were selected as the research subjects and set as the study group.Pregnant women with anemia in the research group were divided into early pregnancy(n=34),mid pregnancy(n=72),and late pregnancy(n=44)according to different stages of pregnancy.The severity and type of anemia in patients were determined based on the test results,and the severity and type of anemia in patients at different gestational weeks were compared.Another 150 healthy pregnant women who underwent examinations at the same hospital during the same period were selected as the control group.The blood routine levels of hemoglobin(Hb),red blood cells(RBC),mean corpuscular hemoglobin content(MCH),red blood cell distribution width(RDW),mean corpuscular volume(MCV),and mean corpuscular hemoglobin concentration(MCHC)were compared between the two groups and during different stages of pregnancy.We collected adverse pregnancy outcomes from the control group and the study group,and used Pearson method to analyze the correlation between blood routine test indicators and adverse pregnancy outcomes.Results With changes in pregnancy,the proportion of moderate anemia significantly increases.The distribution of anemia severity in different stages of pregnancy was compared,and the difference was statistically significant(P＜0.05).Early and mid-pregnancy are mostly characterized by small cell anemia,while late pregnancy is mostly characterized by large cell anemia.The distribution of large and small cell anemia in pregnant women at different stages of pregnancy was compared,and the difference was statistically significant(P＜0.05).RBC,Hb,HCT,MCV,MCH,and MCHC of pregnant anemia patients in the study group were significantly lower than those in the control group,while RDW was significantly higher than that in the control group(P＜0.05).RBC,Hb,HCT,MCV,MCH,and MCHC of late pregnancy anemia patients were significantly lower than those in mid-pregnancy and early pregnancy,while RDW was significantly higher than those in mid-pregnancy and early pregnancy(P＜0.05).The incidence of adverse pregnancy outcomes in the study group was higher than that in the control group(P＜0.05).Pearson correlation analysis showed that RBC,Hb,HCT,MCV,MCH,and MCHC were positively correlated with adverse pregnancy outcomes(r=0.694,0.722,0.633,0.747,0.652,0.732,all P＜0.05).However,RDW is negatively correlated with adverse pregnancy outcomes(r=-0.835,P＜0.05).Pearson correlation analysis showed that RBC,Hb,HCT,MCV,MCH and MCHC were positively correlated with adverse pregnancy outcome(r=0.616,0.549,0.715,0.627,0.571,0.592,P＜0.05).RDW was negatively correlated with adverse pregnancy outcome(r=-0.710,P＜0.05).Pearson correlation analysis in the second trimester group showed that RBC,Hb,HCT,MCV,MCH and MCHC were positively correlated with the adverse pregnancy outcome(r=0.551,0.521,0.619,0.571,0.492,0.621,P＜0.05).RDW was negatively correlated with adverse pregnancy outcome(r=-0.741,P＜0.05).Pearson correlation analysis showed that RBC,Hb,HCT,MCV,MCH and MCHC were positively correlated with adverse pregnancy outcome(r=0.694,0.691,0.549,0.427,0.672,0.711,P＜0.05).However,RDW was negatively correlated with adverse pregnancy outcome(r=-0.552,P＜0.05).Conclusion Blood routine test indicators in pregnant women with anemia are significantly lower than those in normal pregnant women,and there are significant differences in blood routine treatment levels during different pregnancies.At the same time,there is a correlation between treatment and adverse pregnancy outcomes.
维普
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