Objective To explore and analyze the application value of serum thyroid stimulating hormone(TSH)detection in pregnant women in prenatal screening of Congenital Heart Disease(CHD)in children.Methods From January 2023 to December 2023,2 302 pregnant women who underwent prenatal screening in our institute were selected as the study subjects.Serum TSH level of pregnant women was detected and ultrasound was performed.All newborns delivered by pregnant women were followed up to determine the incidence of congenital heart disease in children.According to TSH level,pregnant women were divided into TSH-negative group(2 257 cases)and TSH-positive group(45 cases).Results The serum TSH content in TSH-positive group was higher than that in TSH-negative group(P＜0.05).The left ventricular ejection fraction of fetuses in TSH-positive group was lower than that in TSH-negative group(P＜0.05).After the follow-up of pregnant women after delivery,36 children were finally determined to be congenital heart disease,accounting for 1.56％.Compared with congenital heart disease,univariate analysis showed that there were statistical differences for pregnant women's age,smoking,TSH level,history of virus infection in early pregnancy,history of exposure to toxic substances,history of adverse pregnancy,and whether regular birth check-up was conducted(P＜0.05).Logistic regression analysis showed that advanced maternal age,smoking history,TSH level in pregnancy examination,viral infection history in early pregnancy and toxic exposure history were risk factors for congenital heart disease in newborns,and regular prenatal examination was protective factor for congenital heart disease in newborns.Among the 2 302 pregnant women,45 cases were TSH positive.The sensitivity,specificity and accuracy of serum TSH level in prenatal screening of children with congenital heart disease were higher than other influencing factors(P＜0.05).Conclusion The incidence of congenital heart disease in children is still relatively high.Serum TSH detection in pregnant women has a high value in prenatal screening for congenital heart disease in children.
万方数据
维普
