Objective To investigate the levels and clinical significance of lipoprotein a,creatinine and cystatin C in patients with diabetic nephropathy(DN).Methods Two hundred patients with type 2 diabetes mellitus(T2DM)admitted from May 2021 to May 2024 were enrolled.According to whether they had DN,they were divided into DN group(n=70)and non DN group(n=130).The baseline data and clinical indicators were compared between DN group and non DN group.The levels of lipoprotein a,creatinine and cystatin C were measured.The relationship between lipoprotein a,creatinine and cystatin C levels and DN was analyzed by binary logistics regression equation.ROC curve was performed to analyze the diagnostic value of lipoprotein a,creatinine and cystatin C levels on DN.Results The urea nitrogen,low-density lipoprotein cholesterol,fasting blood glu-cose,2 hour postprandial blood glucose,hemoglobin and fins fasting insulin in DN group were significantly higher than those in non DN group(P＜0.05),but there were no statistical differences in other indicators(P＞0.05).The levels of lipoprotein a,creatinine and cystatin C in DN group were significantly higher than those in non DN group(P＜0.05).Lipoprotein a,creatinine and cystatin C were correlated with DN(P＜0.05).ROC curve results revealed that the AUC of the three indicators were 0.856,0.746 and 0.799 respectively,and the AUC of combined diagnosis was 0.929,with higher value.Conclusion Elevated levels of lipoprotein a,creatinine and cystatin C can be used to diagnose DN in patients with T2DM,and they are expected to be biochemical markers.
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