Objective To analyze the predictive value of serum microRNA-126(miR-126)and microRNA-143(miR-143)for postoperative disease recurrence in patients with unruptured intracranial aneurysm(UIA).Methods With 102 patients with UIA admitted to our hospital from June 2022 to June 2023.All patients received endovascular embolization treatment,all patients were followed up for six months one year after surgery,and were divided into a recurrence group(32 cases)and a non-recurrence group(70 cases)based on whether their condition recurred.General and clinical data of the two groups of patients were collected for univariate analysis and logistic multivariate regression analysis to summarize the risk factors for postoperative disease recurrence in UIA patients.the predictive value of serum miR-126 and miR-143 for postoperative disease recurrence in UIA was verified by plotting ROC and observing AUC.Results The results of univariate analysis showed that the proportion of hypertension,inflow angle,aneurysm diameter,aneurysm neck width,Raymod grade ≥ Ⅱ after surgery,simple coil embolization,and serum miR-126 in the recurrence group were higher than those in the non-recurrence group,the serum miR-143 was lower than that of the non-recurrent group(all P＜0.05).Logistic multivariate regression analysis showed that inflow angle,aneurysm diameter,immediate Raymod grading after surgery,simple coil embolization,miR-126,and miR-143 were risk factors for postoperative recurrence of UIA.Through ROC curve validation,the sensitivity and specificity of serum miR-126 for predicting postoperative disease recurrence in UIA were 82.26％and 78.44％,respectively.The sensitivity and specificity of serum miR-143 for predicting postoperative disease recurrence in UIA were 80.29％and 77.95％,respectively(AUC＞0.85).Conclusion Excessive inflow angle,long aneurysm diameter,Raymod grade ≥ Ⅱ immediately after surgery,simple coil embolization,and high serum miR-126 expression and low serum miR-143 expression are all risk factors for postoperative disease recurrence in UIA patients.Dynamic monitoring of serum miR-126 and miR-143 levels can achieve early prediction of postoperative recurrence risk in patients.
维普
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