The association between serum growth differentiation factor-11,heme oxygenase-1 and the degree of cardiac dysfunction and the risk of major cardiovascular adverse events chronic heart failure
Objective To analyze the association between growth differentiation factor-11(GDF-11),heme oxygenase-1(HO-1),and the degree of cardiac function impairment and risk of major cardiovascular adverse events(MACE)in patients with chronic heart failure(CHF).Methods A total of 115 patients from Jan 2022 to Jan 2023 with CHF were selected as the study subjects.According to different cardiac function grades of the New York Heart Association(NYHA),55 patients with NYHA grades Ⅰ to Ⅱ were classified as mild group,and 60 patients with NYHA grades Ⅲ to Ⅳ were classified as moderate to severe group.The differences of serum GDF-11,HO-1 and cardiac function indexes between the two groups were compared,and the correlation between serum GDF-11 and HO-1 and cardiac function indexes was examined,as well as the predictive efficacy of serum GDF-11 and HO-1 on the risk of MACE in patients with chronic CHF.Results The serum GDF-11,HO-1,LVEDV and LVESV in the moderate and severe group were(752±50)ng/ml,(25±5)ng/ml,(178±20)ml and(86+10)ml,respectively.All of them were higher than those in mild group[(711±50)ng/ml,(22±5)ng/ml,(163±20)ml,(80±10)ml].LVEF and CO in moderate and severe group were(25±5)％and(62±10)ml/min,respectively,lower than those in mild group[(40+5)％and(67+10)ml/min](t=4.345,2.878,3.942,2.738,-2.994,-2.666;P＜0.05).According to Pearson correlation coefficient test,serum GDF-11 was negatively correlated with LVEF and CO,and positively correlated with LVEDV and LVESV(r=-0.255,-0.525,0.358,0.355;P＜0.05);Serum HO-1 was negatively correlated with LVEF and CO,and positively correlated with LVEDV and LVESV(r=-0.261,-0.258,0.349,0.353;P＜0.05).The incidence of MACE in 115 patients with CHF was 17.39％(20/115).The serum GDF-11,HO-1,LVEDV and LVESV in the occurrence group were(760±50)ng/ml,(26±5)ng/ml,(180±20)ml and(87±10)ml,respectively.All of them were higher than those in the non-occurrence group[(710±50)ng/ml,(21±5)ng/mL,(162±20)ml,(80±10)ml].LVEF and CO in the occurrence group were(36±5)％and(60±10)mL/min,respectively,which were lower than those in the non-occurrence group[(41±5)％and(65±10)ml/min](t=4.041,3.952,3.609,3.004,-3.356,-2.156;P＜0.05);The ratio of sensitivity and specificity of serum GDF-11 to the risk of MACE in CHF patients was 81.35％and 80.24％,and the ratio of sensitivity and specificity of serum HO-1 to the risk of MACE in CHF patients was 80.29％and 78.66％(AUC＞0.85).Conclusion Serum GDF-11 and HO-1 levels will continuously increase with the severity of heart function damage in CHF patients,and dynamic monitoring of changes in their levels can achieve early prediction of the risk of MACE.
维普
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