Objective The aim is to simulate and verify the influencing factors of liquid circulation in liquid phase oxidation desulfurization multi-champer loop reactor.Methods Based on the Euler-Euler multi-phase flow model,the gas-liquid two-phase flow in the liquid phase oxidation desulfurization multi-champer loop reactor was simulated by CFD numerical simulation,and the effects of acid gas volume flow and air volume flow on liquid circulation were investigated.Results The error between the liquid circulation obtained by numerical simulation and the liquid circulation measured by the target flow meter was less than 10%.When the volume fraction of hydrogen sulfide in acid gas did not exceed 3%,the correlation between the liquid circulation(z),acid gas volume flow(x)and air volume flow(y)was as follows:z=-474.996+0.358x+0.487 3y.Conclusion The Euler-Euler two-phase flow model can accurately predict the liquid circulation in the liquid phase oxidation desulfurization reactor.