Effects and mechanisms of DanZhi XiaoYao power on insulin resistance in polycystic ovary syndrome rats
Objective To investigate the effects of DanZhi XiaoYao power (DZXYP) on insulin resistance in polycystic ovary syndrome (PCOS) rats and its regulation on activation of insulin receptor substrate 1 (IRS-1) and Akt. Methods Capsulae Levonorgestreli Silasticus and human chorionic gonadotrophin were used to induce PCOS model in rats. Blood lipid, FBG, FINS, BWGD and OW were measured routinely. Western blot was used to measure activation of IRS-1 and Akt. Results DZXYP ameliorated the cystic expansion of follicles and the disorganized granulosa cells. DZXYP reduced the level of TG, TD, LDL and increased the level of HDL. It decreased FINS and HOMA-IR without effect on FBG. It decreased the BWGD and OW either. DZXYP decreased phosphorylation of IRS-1 307 serine and increased the phosphorylation of Akt 473 serine. Conclusion DZXYP ameliorates the insulin resistance in PCOS rats through decreasing phosphorylation of IRS-1 307 serine and increasing the phosphorylation of Akt 473 serine.
国家科技期刊平台
NSTL
万方数据
维普
