Pyroptosis is a form of programmed cell death with inflammatory characteristics,which has attracted wide attention in the biomedical field in recent years.Pyroptosis plays a crucial role in activating host defenses,promoting inflammatory responses,regulating immune responses,and influencing the tumor microenvi-ronment.In cancer research,the dual role of pyroptosis is particularly significant,which can both inhibit tumor growth and promote tumor development in certain instances.Furthermore,research on pyroptosis offers new per-spectives for cancer treatment,particularly in enhancing the efficacy of traditional chemoradiotherapy,boosting anti-tumor immune responses,and applying nanotherapeutic strategies.This article reviews the regulatory role of pyroptosis in cancer progression,as well as its theoretical basis and practical applications as a potential anti-cancer strategy,with the aim of providing new insights and directions for the development of cancer treatment strategies in the future.
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