The effect of aspirin on frozen thawed embryo transfer in endometriosis with thin endometrium
Objective To analyze the effect of aspirin addition on endometrial conditions and pregnancy outcomes in endometriosis-related patients with thin endometrium.Methods A retrospective analysis was conducted on endometriosis-related patients with thin endometrium(thickness<7 mm)undergoing frozen-thawed embryo transfer at the Reproductive Medical Centre from January 2019 to May 2023 was conducted.Patients undergoing hor-mone replacement therapy with aspirin(Observation group,n=162)were compared with those receiving increased estrogen alone(Control group,n=152).Endometrial parameters before embryo transfer and clinical outcomes were compared between the groups.Results Compared to the Control group,the Observation group showed significant improvements in pulsatility index(PI)[(0.77±0.20)vs.(0.84±0.27),P<0.05],resistance index(RI)[(0.49±0.10)vs.(0.63±0.10),P<0.01],and systolic/diastolic(S/D)ratio[(1.94±0.49)vs.(2.22±0.47),P<0.01].Moreover,there was a significant increase in the embryo implantation rate(38.00%vs.27.24%,P<0.01),clinical pregnancy rate(56.17%vs.42.11%,P<0.05)and live birth rate(84.62%vs.68.75%,P<0.05).Conclusion In endometriosis-related patients with thin endometrium,the addition of aspirin significantly improved uterine and spiral artery blood flow,thereby enhancing pregnancy outcomes during frozen-thawed embryo transfer.
endometriosisthin endometriumaspirinfrozen embryo transfer
万方数据
维普
