摘要
近年来我国结直肠癌发病率和病死率逐年上升,治疗采用手术辅以放化疗、靶向治疗、免疫治疗等的综合方案,但多数患者就诊时已处于晚期,失去根治性切除手术的机会,5年生存率低.CAR-T细胞是将应用基因修饰技术制备表达CAR的T淋巴细胞经体外扩增后再回输至患者体内的一种个体化治疗方法,在治疗急性淋巴细胞白血病中取得了突破性进展,治疗食管癌、胃癌、乳腺癌和结直肠癌等实体瘤的研究也在广泛开展.本文就CAR-T细胞的原理、治疗结直肠癌的主要靶点、目前存在的问题作一综述.
Abstract
In recent years,the incidence and fatality rate of colorectal cancer have increased year by year in China.The patients receive a comprehensive treatment plan including surgical treatment,adjuvant chemoradiotherapy,targeted therapy,immunotherapy,etc.However,most patients are in the advanced stage when they visit doctor,loosing surgery opportunity,therefore the 5-year survival rate is low.CAR-T cell therapy is an individualized plan to re-infuse chimeric receptor T lymphocytes prepared by gene modification technology after expanding in vitro into patients,and it has made a breakthrough in the treatment of acute lymphoblastic leukemia.CAR-T cell therapy on solid tumors such as esophageal cancer,stomach cancer,breast cancer and colorectal cancer has also been widely carried out.This paper reviews the research progress of the principle,main targets and existing problems of CAR-T cell therapy for colorectal cancer.
基金项目
河南省医学科技攻关计划省部共建重点项目(SBGJ202102025)
NETL
NSTL
维普
万方数据