急性胰腺炎自噬受损与细胞器相互作用的研究进展
Research progress of the interaction between impaired autophagy and organelles in acute pancreatitis
刘康豪 1戴胜兰1
作者信息
- 1. 江苏大学附属人民医院镇江市第一人民医院消化内科,江苏镇江 212000
- 折叠
摘要
急性胰腺炎发病机制多样,具体机制尚未阐明.细胞器是散布在细胞质内具有一定形态和功能的微结构或微器官,在胰腺腺泡细胞功能的正常运转中起重要作用.细胞器参与自噬过程,自噬促进细胞器的更新,二者相互协调维持细胞状态的稳定.细胞器及自噬受损参与急性胰腺炎的发生、发展.本文就急性胰腺炎中自噬与细胞器的相互作用、自噬受损在急性胰腺炎发生中作用的研究进展作一综述.
Abstract
The pathogenesis of acute pancreatitis is diverse,and the specific mechanisms are not yet fully elucidated.Organelles are micro-structures or micro-organs with certain morphology and function scattered in the cytoplasm,which play an important role in the normal function of pancreatic acinar cells.Organelles participate in autophagy process,autophagy promotes the renewal of organelles,and both of them coordinate to maintain the stability of cell state.The dysfunction of organelles and autophagy are involved in the occurrence and development of acute pancreatitis.This paper reviews the research progress of interaction between autophagy and organelles in acute pancreatitis and the affect of autophagy dysfunction on the pathogenesis of acute pancreatitis.
关键词
急性胰腺炎/自噬/细胞器Key words
acute pancreatitis/autophagy/organelles引用本文复制引用
基金项目
江苏省自然科学基金(BK20181225)
出版年
2024
NETL
NSTL
维普
万方数据