Values of soluble fms-like tyrosine kinase-1/placental growth factor and 25-hydroxyvitamin D3 to the prediction of preeclampsia
Objective To observe the changes of serum soluble fms-like tyrosine kinase-1(sFlt-1)/placental growth factor(PLGF)and 25-hydroxyvitamin D3[25(OH)D3]in pregnant women with preeclampsia,and to explore their values to the prediction of preeclampsia.Methods Sixty pregnant women with preeclampsia(preeclampsia group)received regular prenatal examinations and gave birth in Maternal and Child Health Care Hospital Affiliated to Anhui Medical University from January 2020 to September 2022,and another 248 normal pregnant women without pregnancy complications or comorbidities were as controls(control group).The age,pre-pregnancy body mass index,number of pregnancies,gestational age at delivery,body mass of neonates,and blood pressure were compared between two groups.The serum levels of 25(OH)D3,sFlt-1 and PLGF were measured by electrochemiluminescence,and the sFlt-1/PLGF ratio was calculated.ROC curves were plotted to assess the efficiencies of serum 25(OH)D3 and sFlt-1/PLGF on predicting preeclampsia.Results The gestational age at delivery was shorter in preeclampsia group[(38.11± 2.01)weeks]than that in control group[(39.01±1.48)weeks](t=2.321,P=0.026).The body mass of neonates and serum 25(OH)D3 level were lower in preeclampsia group[(3 018.33±602.82)g,(54.41±16.98)nmol/L]than those in control group[(3 325.89±480.44)g,(66.58±23.15)nmol/L](t=2.987,P=0.003;t=2.707,P=0.008).The systolic blood pressure,diastolic blood pressure and sFlt-1/PLGF ratio were higher in preeclampsia group[(158.98± 13.92)mmHg,(94.36±9.63)mmHg,25.61±14.95]than those in control group[(108.14±10.65)mmHg,(66.89±8.37)mmHg,19.78±12.59](P＜0.05),and there were no significant differences in the age,pre-pregnancy body mass index and number of pregnancies between two groups(P＞0.05).The AUC of serum 25(OH)D3 for predicting preeclampsia was 0.346(95％CI:0.238-0.454,P=0.076),with a sensitivity of 100.0％and a specificity of 0.When the optimal cut-off value of sFlt-1/PLGF was 13,the AUC for predicting preeclampsia was 0.605(95％CI:0.502-0.707,P=0.006),with a sensitivity of 90.0％and a specificity of 37.9％.The AUC of the combination of serum 25(OH)D3 and sFlt-1/PLGF for predicting preeclampsia was 0.708(95％CI:0.610-0.815,P＜0.001),with a sensitivity of 70.0％and a specificity of 62.9％.Conclusion The serum 25(OH)D3 level reduces in pregnant women with preeclampsia,while sFlt-1/PLGF increases,and the combination of them two has a high predictive value.
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