NLRP6炎症小体在肝脏疾病中作用研究进展
Advances in NLRP6 inflammasome in liver diseases
赵丹阳 1赵悰怡 1张钊龙 2郑卉 2秦秉玉1
作者信息
- 1. 河南大学人民医院河南省人民医院重症医学部,河南郑州 450003
- 2. 河南省人民医院郑州大学人民医院重症医学部,河南郑州 450003
- 折叠
摘要
核苷酸结合寡聚化结构域样受体(NLR)是一类模式识别受体,其中NLRP6是NLR家族新成员.NLRP6炎症小体在炎性反应、维持肠道微生态、调控病毒感染中有重要作用,参与酒精性肝病、肝细胞癌及脓毒症肝损伤等肝脏疾病的发生、发展.本文就NLRP6炎症小体的结构、功能、激活机制及其在肝脏疾病中作用的研究进展作一综述.
Abstract
Nucleotide-binding and oligomerization domain-like receptor(NLR)is a pattern recognition receptor.NLRP6 is a new member of the NLR family.NLRP6 inflammasome plays an important role in inflammatory responses,maintenance of intestinal homeostasis,and regulating viral infection,and participates in the progression of liver diseases such as alcoholic liver disease,hepatocellular carcinoma,and septic liver injury.This paper reviews the research progress of the structure,function and activation mechanism of NLRP6 inflammasome and its role in various liver diseases.
关键词
肝脏疾病/NLRP6炎症小体/酒精性肝病/肝细胞癌/脓毒症肝损伤Key words
liver diseases/NLRP6 inflammasome/alcoholic liver disease/hepatocellular carcinoma/septic liver injury引用本文复制引用
基金项目
河南省科技研发专项项目(202300410458)
出版年
2024
NETL
NSTL
万方数据