Nucleotide-binding and oligomerization domain-like receptor(NLR)is a pattern recognition receptor.NLRP6 is a new member of the NLR family.NLRP6 inflammasome plays an important role in inflammatory responses,maintenance of intestinal homeostasis,and regulating viral infection,and participates in the progression of liver diseases such as alcoholic liver disease,hepatocellular carcinoma,and septic liver injury.This paper reviews the research progress of the structure,function and activation mechanism of NLRP6 inflammasome and its role in various liver diseases.
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