Relationship between retinal transient ischemic attack and central visual acuity in eyes with non-arteritic central retinal artery occlusion
Objective To observe the changes in central visual acuity in patients with non-arteritic central retinal artery occlusion(NA-CRAO)with or without a history of retinal transient ischemic attack(RTIA),and to explore the role of RTIA in protecting central visual acuity.Methods Totally 175 patients(175 eyes)with NA-CRAO in Henan Provincial People's Hospital from January 2016 to June 2023 were divided into 95 patients(95 eyes)without RTIA history(non-RTIA group),38 patients(38 eyes)with ≤2 weeks from RTIA onset to NA-CRAO onset(short-term RTIA group)and 42 patients(42 eyes)with＞2 weeks from RTIA onset to NA-CRAO onset(long-term RTIA group).The gender,age,comorbidities(hypertension,diabetes,hypercholesterolemia,coronary artery disease),smoking habits,alcohol consumption history,history of cerebral infarction,time from onset to visit,and length of hospital stay were compared among three groups.All patients underwent optical coherence tomography on admission to measure the central retinal thickness(CRT)of both affected and healthy eyes.All three groups received conservative treatment.The best-corrected visual acuity(BCVA)of the affected eyes was tested on admission and after 1-and 3-month treatment.The BCVA was converted to logMAR visual acuity,and the improvement rate of central visual acuity was compared.Results(1)There were no significant differences in the age,time from onset to visit,length of hospital stay,male ratio,and percentages of patients with smoking habits,alcohol consumption history,history of cerebral infarction,and comorbidities as hypertension,diabetes,hypercholesterolemia and coronary artery disease among three groups(P＞0.05).(2)There was a significant difference in the CRT of the affected eyes among three groups(F=17.771,P＜0.001),while there was no significant difference in the CRT of the healthy eyes(F=2.084,P=0.128).The CRT on admission was thinner in short-term RTIA group[(308.39±34.46)μm]than that in long-term RTIA group[(341.00±44.38)μm]and non-RTIA group[(360.74±50.40)μm](P＜0.05),and showed no significant difference between long-term RTIA group and non-RTIA group(P＞0.05).(3)There were significant differences in the BCVA(logMAR)on admission and after 1-and 3-month treatment among three groups(F=3.107,P=0.047;F=3.668,P=0.028;F=4.737,P=0.010),and the BCVA(logMAR)showed no significant difference after 1-and 3-month treatment compared with that on admission(P＞0.05).The BCVA(logMAR)values on admission and after 1-and 3-month treatment were lower in short-term RTIA group(2.10±0.88,2.00±0.88,1.90±0.86)than those in long-term RTIA group(2.46±0.81,2.37±0.80,2.31±0.78)and non-RTIA group(2.47±0.77,2.40±0.76,2.35±0.75)(P＜0.05),and showed no significant differences between long-term RTIA group and non-RTIA group(P＞0.05).(4)There were no significant differences in the improvement rates of central visual acuity of the affected eyes after 1-and 3-month treatment among short-term RTIA group(18.4％,26.3％),long-term RTIA group(14.3％,23.8％),and non-RTIA group(13.7％,20.0％)(P＞0.05).Conclusion RTIA in a short interval with NA-CRAO has a protective role in the central visual acuity of the affected eyes.
retinal transient ischemic attacknon-arteritic central retinal artery occlusioncentral visual acuity
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