线粒体自噬及生物发生与微血管缺血再灌注损伤关系的研究进展
Relationships of mitophagy and organisms with ischemia-reperfusion related microvascular injury
黄士蒙 1李小妹 1蒋振雄 1赵思玉 1高渊博 1王好 1陶艾彬1
作者信息
- 1. 江苏大学附属人民医院心血管内科,江苏镇江 212001
- 折叠
摘要
线粒体是细胞中制造能量的细胞器,是细胞有氧呼吸的主要场所,其氧化磷酸化提供的能量可维持生命活动.线粒体功能障碍与多种疾病如心血管疾病、糖尿病等的发生、发展相关.线粒体参与多种细胞功能的调控,控制细胞程序性死亡,对微血管内皮细胞的存活起重要作用.线粒体质量控制系统调节线粒体的结构及功能,包括线粒体生物发生、线粒体分裂、线粒体融合及线粒体自噬.本文就线粒体生物发生、自噬相关的分子机制及其与微血管缺血再灌注损伤关系的研究进展作一综述.
Abstract
Mitochondria are energy-generating organelles presented in most cells and are the main places for aerobic respiration.Mitochondrial oxidative phosphorylation provides the energy to maintain life activities.Mitochondrial dysfunction is closely related with the onset and development of many diseases,such as cardiovascular diseases and diabetes mellitus.Mitochondria are crucial for the survival of microvascular endothelial cells due to their roles in metabolic energy production and regulation of programmed cell death.Mitochondrial quality control system regulates mitochondrial structure and function,including mitochondrial biogenesis,mitochondrial fission and fusion,and mitophagy.This paper reviews the research progress of molecular mechanisms underlying mitophagy and mitochondrial biogenesis,and relationship with microvascular ischemia-reperfusion injury.
关键词
线粒体自噬/线粒体生物发生/缺血再灌注损伤/内皮细胞/微血管损伤Key words
mitophagy/mitochondrial biogenesis/ischemia-reperfusion injury/endothelial cells/microvascular injury引用本文复制引用
出版年
2024
NETL
NSTL
万方数据