Research progress of the application of circRNA in cholangiocarcinoma
Cholangiocarcinoma has a hidden onset,high malignancy,and poor prognosis.Because of its non-specific early symptoms,it is difficult to make diagnosis.CircRNA is a type of non-coding RNA with a covalent closed loop structure.It is expressed stably in cells,with a high biological conservation,high expression abundance,tissue specificity,and developmental stage specificity.It is abnormally expressed in various tumors such as lung cancer,liver cancer,gastric cancer,esophageal cancer,etc.The expression of circRNA varies in different stages of cholangiocarcinoma,and may be involved in the occurrence and development of cholangiocarcinoma.This paper reviews the research progress of the origin and characteristics of circRNA,as well as its role and mechanism in cholangiocarcinoma.
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