Roles of brain lactate metabolism and astrocytome-neuron lactate shuttle in neuronal activity and neurological diseases
Lactate is an end product of anaerobic glycolysis of glucose and is considered to be a metabolic waste,but it can be used as an energy source by brain when the glucose is absent,energy demand increases and oxygen supply reduces.Being an intermediate molecule for the metabolism of neurons and astrocytes,lactate plays a protective role in brain function and neurological diseases.This paper reviews the research progress of the roles of brain lactate metabolism and astrocytome-neuron lactate shuttle in the neuronal activity and neurological diseases.
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