Relationship between serum myeloperoxidase and male metabolic syndrome
Objective To observe the changes of serum myeloperoxidase(MPO)in male patients with metabolic syndrome(MS),and to investigate its predictive value.Methods Totally 811 male patients received physical examination in the First Affiliated Hospital of Xinjiang Medical University from February to April,2023,and were divided into MS group(n=458)and non-MS group(n=353).The serum MPO level was detected by colloidal gold method.The general clinical data as age,hypertension history and serum MPO level were compared between two groups.Multivariate logistic regression analysis was done to assess the influencing factors of MS in male patients.Restricted cubic spline plots were used to analyze the dose-response relationship between MPO and MS.ROC curve was plotted to evaluate the efficiency of MPO on predicting MS.Results The patients were older in MS group[63.0(58.0,68.0)years]than non-MS group[60.0(56.0,65.0)years](U=193.063,P＜0.001),the proportions of hypertension history,coronary artery disease,diabetes,use of antihypertensive drugs,use of antihyperglycaemic drugs,body mass index,waist circumference,systolic blood pressure,diastolic blood pressure,white blood cell count,neutrophil count,lymphocyte count,and serum levels of MPO,fasting plasma glucose,glycosylated hemoglobin,albumin and triacylglycerol were higher in MS group[81.9％,26.6％,41.7％,42.1％,26.4％,26.6(24.8,28.5)kg/m2,96.0(92.0,102.0)cm,137.0(128.0,148.0)mmHg,83.0(76.0,90.0)mmHg,6.47(5.50,7.52)×109/L,3.61(2.87,4.36)× 109/L,2.07(1.69,2.53)× 109/L,85.5(75.0,97.8)μg/L,5.81(5.21,6.80)mmol/L,6.14(5.64,6.74)％,45.4(43.9,46.8)g/L,1.81(1.30,2.38)mmol/L]than those in non-MS group[50.7％,16.7％,5.1％,22.7％,4.8％,25.5(24.2,27.6)kg/m2,94.0(89.0,98.0)cm,128.0(120.0,139.0)mmHg,80.0(73.0,86.0)mmHg,5.74(4.92,6.84)× 109/L,3.08(2.51,3.81)× 109/L,2.00(1.67,2.40)× 109/L,77.0(67.0,90.0)μg/L,4.96(4.63,5.23)mmol/L,5.52(5.30,5.82)％,44.8(43.1,46.3)g/L,1.19(0.92,1.46)mmol/L](P＜0.05),the estimated glomerular filtration rate,total cholesterol,high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were lower in MS group[95.1(87.4,102.0)％,4.27(3.48,5.06)mmol/L,1.10(0.97,1.26)mmol/L,2.78(2.15,3.38)mmol/L]than those in non-MS group[98.1(91.3,103.0)％,4.48(3.84,5.11)mmol/L,1.25(1.13,1.41)mmol/L,2.96(2.43,3.46)mmol/L](P＜0.05),and there were no significant differences in the ethnicity,smoking habits,alcohol consumptions,red blood cell count and total bilirubin level between two groups(P＞0.05).The age(OR=1.048,95％CI:1.004-1.093,P＜0.001),history of hypertension(OR=4.035,95％CI:2.260-17.203,P＜0.001),history of diabetes(OR=13.851,95％CI:4.524-42.412,P＜0.001),serum MPO(OR=1.027,95％CI:1.014-1.039,P＜0.001),fasting plasma glucose(OR=2.516,95％CI:1.678-3.771,P＜0.001),albumin(OR=1.176,95％CI:1.061-1.303,P＜0.001),triacylglycerol(OR=7.632,95％CI:4.459-13.061,P＜0.001),and high-density lipoprotein cholesterol(OR=0.030,95％CI:0.004-0.225,P＜0.001)were the influencing factors of MS in male patients.The serum MPO level was linearly correlated with the prevalence of MS,and it tended to increase with the elevation of MPO level.When the optimal cut-off value of serum MPO was 73.5 μg/L,the AUC for predicting MS was 0.635(95％CI:0.597-0.673,P＜0.001),with a sensitivity of 79.0％and a specificity of 41.6％.Conclusion The advanced age,male,history of hypertension,history of diabetes,increased levels of serum MPO,fasting plasma glucose,albumin and triacylglycerol,and decreased level of high-density lipoprotein cholesterol increase the risk of MS,and the serum MPO level has a predictive value for MS in male patients.
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