Ultrasound is a common imaging examination and physical therapy method in clinical practice.Sonogenetics uses ultrasound to selectively modulate cells which are genetically engineered with sound-sensitive proteins,and it can be used to manipulate cell functions,with non-invasive and enhanced spatial focus.Sonogenetics is expected to be a new therapeutic strategy for neurological diseases,cardiovascular diseases and tumor-related diseases.To find the right sound-sensitive protein is the main challenge to develop the technology of sonogenetics.This paper reviews the research progress of sonogenetics.