Progress in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy is a cerebral small vessel disease caused by Notch3 gene mutation.Notch3 protein encoded by Notch3 gene is mainly expressed in vascular smooth muscle cells,pericytes and endothelial cells.Notch3 gene mutation leads to the changes in the structure and function of Notch3 protein,which affects the structure and function of vascular smooth muscle cells,pericytes and endothelial cells,causes neurovascular dysfunction such as abnormal cerebral blood flow regulation,and ultimately leads to cerebral small vessel disease.This paper reviews the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathyvascular smooth muscle cellpericyteendothelial cell
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