长链非编码RNA在去势抵抗性前列腺癌中调控机制研究进展
Regulatory mechanism of long non-coding RNA in castration-resistant prostate cancer
黄劲峰 1方欢 2韩浩冉 1任瑞民3
作者信息
- 1. 山西医科大学第三医院泌尿外科,山西太原 030032
- 2. 山西医科大学第三医院妇产科,山西太原 030032
- 3. 山西白求恩医院山西医学科学院同济山西医院泌尿外科,山西太原 030032
- 折叠
摘要
随着中国人口老龄化及生活方式改变,前列腺癌发病率逐年上升,晚期常进展为去势抵抗性前列腺癌,对传统的雄激素剥夺疗法产生耐药性,预后不佳,病死率高.长链非编码RNA(lncRNA)通过调控细胞代谢、表观遗传修饰及信号通路等,在前列腺癌细胞生长、增殖、转移及耐药等过程中发挥重要作用,参与去势抵抗性前列腺癌的发生、发展.lncRNA可能在去势抵抗性前列腺癌治疗中具有潜在的应用前景.本文就lncRNA在去势抵抗性前列腺癌中调控机制的研究进展作一综述.
Abstract
With the population aging and lifestyle change in China,the incidence of prostate cancer is increasing year by year.Advanced stages often progress to castration-resistant prostate cancer(CRPC),which develops resistance to traditional androgen deprivation therapy,leading to poor prognosis and high fatality rate.Long non-coding RNA plays an important role in the growth,proliferation,metastasis and drug resistance of prostate cancer cells via regulating cell metabolism,epigenetic modifications and signaling pathways,and it is involved in the occurrence and development of CRPC.Long non-coding RNA may have a potential application prospect in the treatment of CRPC.This paper reviews the research progress of the regulatory mechanism of long non-coding RNA in CRPC.
关键词
去势抵抗性前列腺癌/长链非编码RNA/耐药/调控机制/治疗靶点Key words
castration-resistant prostate cancer/long non-coding RNA/drug resistance/regulatory mechanism/therapeutic targets引用本文复制引用
基金项目
中央引导地方科技发展资金项目(YDZJSX20231A066)
出版年
2024
NETL
NSTL
万方数据