Regulatory mechanism of Klotho in diabetic kidney disease
Diabetic nephropathy is one of the microvascular complications of diabetes,which would finally progress to end-stage renal disease,with multi-system complications,and seriously affects the life quality and life span of patients.Klotho is mainly expressed in renal tubular epithelial cells,with the functions as anti-aging,anti-apoptosis,anti-oxidation,and regulating calcium-phosphorus metabolism.It is involved in the regulation of macrophage polarization,oxidative stress and various signaling pathways,and plays a role in delaying the progression of renal fibrosis,which might be a potential therapeutic target for diabetic nephropathy.This paper reviews the research progress of the regulatory mechanism of Klotho in diabetic nephropathy.
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