Mechanisms of extracellular vesicles in the progression of castration-resistant prostate cancer
Extracellular vesicles(EVs)are nanoscale vesicles released by cells into the external environment,playing a significant role in the progression of various tumors,including castration-resistant prostate cancer(CRPC).EVs mediate communication between tumor cells and the tumor microenvironment by transferring functional molecules such as proteins,nucleic acids and lipids,as to exert multiple regulatory effects in the development and progression of CRPC.The molecules such as miRNA and lncRNA within EVs can regulate androgen receptor signaling pathways to influence the resistance of prostate cancer cells to androgen deprivation therapy.EVs can promote the proliferation,invasion and migration of CRPC cells or enhance tumor survival and resistance by altering the cellular composition and functional characteristics of the tumor microenvironment.EVs play an important role in the progression of CRPC,therefore,to understand their regulatory mechanisms is of great significance for the development of new diagnostic and therapeutic strategies.This paper reviews the research progress of the mechanisms of EVs in the progression of CRPC.
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