以补体为靶点治疗狼疮性肾炎研究进展
Progress of targeting complement for lupus nephritis
李露 1李林淋 1曹慧霞 1阎磊1
作者信息
- 1. 郑州大学人民医院河南省人民医院肾内科河南省肾病临床医学研究中心河南省肾脏病免疫重点实验室,河南郑州 450003
- 折叠
摘要
狼疮性肾炎是系统性红斑狼疮的肾脏损害,约50％以上系统性红斑狼疮患者有肾脏受累的临床表现,狼疮性肾炎也是我国终末期肾病的重要原因之一.目前狼疮性肾炎的发病机制尚未完全明确,但公认的发病机制是肾脏局部免疫复合物形成与沉积导致补体过度激活,从而导致肾脏局部炎性反应及损伤.补体系统在狼疮性肾炎发病中发挥关键作用,有望成为狼疮性肾炎新的治疗靶点.本文就以补体为靶点治疗狼疮性肾炎的研究进展作一综述.
Abstract
Lupus nephritis(LN)is the kidney damage of systemic lupus erythematosus,more than 50％of systemic lupus erythematosus patients have clinical manifestations of renal involvement,and LN is also one of the most important causes of end-stage renal disease in China.At present,the pathogenesis of LN has not been fully defined,but it is generally acknowledged that the formation and depositions of local immune complexes in the kidney lead to over-activation of the complement system,which leads to local inflammatory response and injury to the kidney.The complement system plays a key role in the pathogenesis of LN and is expected to become a novel therapeutic target for LN.This paper reviews the research progress of complement-targeting in the treatment of LN.
关键词
狼疮性肾炎/系统性红斑狼疮/补体系统/靶向治疗Key words
lupus nephritis/systemic lupus erythematosus/complement system/targeted therapy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据