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毛钩藤碱在抗肿瘤作用中的研究进展

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毛钩藤碱是从传统中药钩藤中提取的吲哚生物碱,已经展现出了丰富的药理活性,包括降压、抗感染和心脏保护等.在宫颈癌、乳腺癌和结肠癌等恶性肿瘤中,毛钩藤碱通过调控细胞凋亡、免疫调节等多种途径产生抗肿瘤效果,为毛钩藤碱在癌症治疗领域的应用奠定了基础.本文通过梳理国内外相关文献,阐述毛钩藤碱在抗肿瘤方面的研究进展,为癌症治疗提供新的思路和策略.
Research progress in the effect of Hirsutine on antitumor
Hirsutine,an indole alkaloid extracted from the traditional Chinese herb Uncaria,has exhibits diverse pharmaco-logical activities,including antihypotensive,antiinfective,and cardioprotection.In cervical cancer,breast cancer,colon cancer,and oth-er malignant tumors,hirsutine has effects on anti-tumor by regulating cell apoptosis,immune regulation and other pathways,laying the foundation for the application of hirsutine in the field of cancer therapy.This article reviews relevant literature both domestically and internationally to elucidate the research progress of hirsutine in anti-tumor therapy,providing new ideas and strategies for cancer treat-ment.

HirsutineAntitumorMechanisms of actionPharmacological effects

于大海、王战士、赵丽珠

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哈尔滨商业大学药学院(哈尔滨 150078)

毛钩藤碱 抗肿瘤 作用机制 药理作用

黑龙江省普通高等学校青年创新人才培养计划项目

UNPYSCT-2020222

2024

实用肿瘤学杂志
黑龙江省,辽宁省,吉林省肿瘤防治办公室

实用肿瘤学杂志

CSTPCD
影响因子:0.528
ISSN:1002-3070
年,卷(期):2024.38(2)
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