Research progress of Claudin family proteins in inflammatory bowel disease and colitis associated colorectal cancer
In recent years,the generation,maintenance and regulation of the intestinal mucosal barrier have become a re-search focus in the occurrence,development,treatment,and prognosis of inflammatory bowel disease(IBD)and colitis associated color-ectal cancer(CAC).Tight junction(TJ)proteins are an important component of the intestinal mucosal barrier,which the Claudin fami-ly proteins have become a research hotspot.This review mainly introduces the changes of Claudin protein in IBD and CAC,as well as the latest research progress on its role in the occurrence,development and clinical treatment of IBD and CAC.
Claudin proteinInflammatory bowel diseaseColorectal cancer associated with enteritisIntestinal barrierTight junction protein
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