摘要
构建符合人类肝癌生物学特性的实验小鼠模型,对于了解肝癌的发病机制和测试新的治疗药物至关重要.目前,实验室常用的肝癌小鼠模型从构建方法上主要分为化学/饮食诱导小鼠模型、基因工程小鼠模型和移植小鼠模型三种类型.同时这三种类型的肝癌小鼠在构建方式、适用范围和肝癌组织类型的特点上也都各不相同.本综述描述不同肝癌小鼠模型的构建方式、成瘤时间以及适用范围,旨在为研究者在选取小鼠模型方面提供参考.
Abstract
The constructing experimental mouse models that conform to the biological characteristics of human liver cancer are crucial for understanding the pathogenesis of liver cancer and testing new therapeutic drugs.At present,the commonly used labora-tory mouse models for liver cancer are mainly divided into three types based on their construction methods:chemically/diet-induced mouse models,genetically engineered mouse models,and transplanted mouse models.However,these three types of liver cancer mice also differ in their construction methods,scope of application,and characteristics of liver cancer tissue types.This review describes the differences in construction methods,tumor formation time,and applicability among different liver cancer mouse models,aiming to pro-vide a reference for researchers in selecting suitable mouse models.
NETL
NSTL
万方数据