Temporal trends of burden and risk factors of early-onset cancer in China from 2000 to 2019
Objective To reveal the trends of the burden and risk factors of early-onset cancer in China from 2000 to 2019.Methods Data were obtained from the 2019 Global Burden of Disease Study.Indicators including incidence,mortality,and disability-adjusted life year(DALY)were used to describe the burden of early-onset cancer in population aged 15 to 49 years,and the population attributable fraction(PAF)of DALY was used to estimate the proportion attributable to modifiable risk factors.Estimated annual percentage change(EAPC)and its 95％CI were applied to estimate the temporal trends of the burden of early-onset cancer from 2000 to 2019.Results In 2019,the rates of incidence,mortality,and DALY of early-onset cancer were 109.0/100 000,35.8/100 000,and 1 763.7/100 000,respec-tively.Early-onset breast cancer,colorectal cancer,and stomach cancer accounted for the highest proportion of newly-diagnosed cases for all early-onset cancers;early-onset lung cancer,liver cancer,and stomach cancer accounted for the highest proportion of death cases for all early-onset cancers.35.8％DALYs imposed by early-onset cancer were attributable to modifiable risk factors.Tobacco use(PAF=16.0％)was the leading risk factor of early-onset cancer,followed by dietary risks(6.1％)and alcohol use(5.9％).From 2000 to 2019,the inci-dence rate of early-onset cancer increased(EAPC=2.0％,95％CI:1.6％-2.3％),whereas the rates of mortality(EAPC=-1.1％,95％CI:-1.4％--0.7％)and DALY(EAPC=-1.2％,95％CI:-1.5％--0.8％)decreased.The proportion of incident cases of early-onset liver cancer decreased in rank from the first position in 2000 to the 8th position in 2019;the proportion of incident cases of early-onset colorectal cancer increased in rank from the 6th position in 2000 to the second position in 2019.Compared with 2000(32.0％),PAF for the risk factors of early-onset cancer increased by 11.9％in 2019.Conclusions The incidence of early-onset cancer increased in China,whereas mor-tality and disability had been effectively controlled.The change in proportions of different early-onset cancers showed heterogeneity.It is significantly important to strengthen interventions for risk factors to reduce the burden of early-onset cancer.
万方数据
