Value of MRI morphological characteristics and apparent diffusion coefficient in diagnosing mesenchymal transition high-grade serous ovarian carcinoma
Objective To explore the value of MRI morphological characteristics and apparent diffusion coefficient(ADC)in diagnos-ing mesenchymal transition high-grade serous ovarian carcinoma(HGSOC).Methods A total of 65 patients with HGSOC pathologically proven via surgery or biopsy at Zhongshan Hospital of Fudan University from January 2014 to January 2020 were retrospectively analyzed.All patients underwent MRI examination before surgery including diffusion weight imaging(DWI).The postoperative pathological sections of all patients were reviewed and classified into mesenchymal transition and non-mesenchymal transition groups.The MRI morphological characteristics including the maximum diameter of the lesion,focal element,whether the adjacent intestinal tract was invaded,whether the retroperitoneal lymph node was enlarged and the volume of ascites,and the volume and ADC of solid components were compared between the two groups.Receiver operating characteristic(ROC)curves were used to evaluate their efficiency in the differential diagnosis of mesen-chymal transition and non-mesenchymal transition HGSOC.Results Among 65 HGSOC patients,28 were mesenchymal transition cases and 37 were non-mesenchymal transition cases.Compared with the non-mesenchymal transition group,the mesenchymal transition group frequently demonstrated predominantly solid mass(P＜0.05);the maximum diameter of the lesion and ADC of solid components in the mesenchymal transition group were lower than those in the non-mesenchymal transition group(both P＜0.05).When the maximum diameter of the lesion was ≤54.50 mm and the ADC of solid components was ≤1.04 × 10-3 mm2/s,the areas under the curves(AUCs)were 0.715 and 0.685,respectively.When the optimal cut off values of the maximum diameter of the lesion and the ADC of solid components were at 52.00 mm and 0.99 x 10-3 mm2/s,respectively,the AUC for their combination was 0.737,with a sensitivity of 71.4％and a specificity of 67.6％.There were no statistical differences between the two groups in the volume of solid components,the invasion of adjacent intestinal tract,the enlargement of retroperitoneal lymph nodes and the volume of ascites.Conclusions MRI morphological characteristics combined with ADC can help distinguish mesenchymal transition HGSOC from non-mesenchymal transition subtype,and provide more information for individu-alized treatment of HGSOC.
万方数据
维普
