Cervical cancer is a malignant tumor with clear etiology and prevention strategy.Although human papillomavirus(HPV)vac-cination and cervical cancer screening have been widely carried out,the incidence of cervical cancer is still rising year by year and showing a trend of younger age.It suggests that the prevention and control of cervical cancer still needs to be improved.Thus,the World Health Organization proposed a global strategy to accelerate the elimination of cervical cancer.With the in-depth study of HPV carcinogenesis,the cervical cancer screening technology continues to innovate.Some new technologies have emerged in recent years,such as extended HPV genotyping,p16INK4a(p16)/Ki-67 dual stain,gene methylation and HPV integration detection.In addition,in order to improve the prog-nosis of patients with cervical cancer,the combinations of neoadjuvant chemotherapy,concurrent chemoradiotherapy,immunotherapy and targeted therapy have become research hotspots.This manuscript reviews the research of cervical cancer in the past ten years.
关键词
子宫颈癌/人乳头瘤病毒疫苗/人乳头瘤病毒初筛/靶向治疗/免疫治疗
Key words
cervical cancer/human papillomavirus vaccination/primary human papillomavirus-based screening/targeted therapy/immunotherapy
维普
万方数据